#3255 BETA2 MICROGLOBULIN IS AN INDEPENDENT PARAMETER RELATED WITH DYSFUNCTION OF NATURAL KILLER CELL ACTIVITY IN HEMODIALYSIS PATIENTS

Abstract Background and Aims End-stage renal disease patients are characterized by immune dysfunction. Natural killer (NK) cells area lymphocytes of innate system that play a key role in an response towards viral infections tumors. We aimed to analyze clinical factors related the NK cell activity chronic hemodialysis (HD) patients. Method Clinically stable 196 who were treated HD for more than 3 months enrolled from 4 outpatient clinics. was assessed using Vue assay (NKMAX, Sungnam, Korea) uses serum ex-vivo stimulated whole blood detect interferon (IFN)-γ secreted as indicator activity. All stratified abnormal (<250 pg/ml) normal (≥250 groups according Results Mean age 62.7 years [range 31 95 years] mean duration 49.2 221 months]. In total, 68 (35%) showed The group significantly increased shorter compared (66.7 ± 11.9 vs. 60.6 13.4 years, p = 0.001; 33.8 33.0 57.5 48.5 months, p<0.001, respectively). albumin parathyroid hormone levels lower (3.7 0.4 3.9 0.3 g/dL, 0.005 176 153 240 260 pg/mL, contrast, hemoglobin, urea nitrogen, reduction ratio, C-reactive protein comparable between two groups. multivariate regression analysis, old age, short dialysis duration, low high beta2 microglobulin independent risk (adjusted odd ratio [AOR], 1.033; 95% confidence interval [CI], 1.005-1.062, 0.02; AOR, 0.981; CI, 0.971-0.992; 0.395; 0.157-0.995; 0.049, 1.042; 1.011-1.075; 0.008, Conclusion Our results suggest young good nutrition well burden middle molecule uremic toxin is associated with greater